Treatment Outcomes among Pediatric Patients with Cervical Pott’s Disease in a Tertiary Care Center A Case Series
Main Article Content
Abstract
Tuberculosis remains a perennial global problem despite advances in detection and treatment. Apart from the pulmonary system, it can also affect the spine of both adult and pediatric patients, with a predilection for the thoracic and lumbar spine. Rarely does spinal TB or Pott’s disease affect the cervical spine and there are few high-level studies in the pediatric population.
Variations are the following: Atlantoaxial/Upper Cervical TB (AATB), Subaxial Cervical TB (SACTB), and Cervicothoracic TB (CTTB). Motor and sensory deficits are more common in CTTB and some SACTB patients while myelopathic signs predominate in AATB patients. The mainstay of treatment for pediatric cervical TB is still anti-tubercular treatment (ATT) using anti-Koch’s medication depending on the level of drug resistance. For some patients, surgery may be indicated with CTTB having the lowest threshold because of its anatomic location. Most patients improve after a year of treatment with at least a 1 Frankel letter grade improvement.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
Tuberculosis. 21 April 2023 [cited 2023 October 12]. https://www.who.int/news-room/fact-sheets/detail/tuberculosis
Low and Middle-income countries. Wellcome Organization; 2023 [cited 2023 October 12]. https://wellcome.org/grant-funding/guidance/low-and-middle-income-countries
Chua J, Mejia C, Berba R. Prevalence, clinical profile, and treatment outcomes of adult patients diagnosed with disseminated tuberculosis seen at University of the Philippines Manila-Philippine General Hospital Tuberculosis Directly Observed Treatment Short Course (TB-DOTS) clinic. Acta Med Philipp. 2017;51(4):300–9.
Rajasekaran S, Soundarajan D, Shetty A, Kanna R, Spinal TB: current concepts. Global Spine J. 2018;8(Suppl 4):96S–108. https://pubmed.ncbi.nlm.nih.gov/30574444 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295815 https://doi.org/10.1177/2192568218769053
Philippine Coalition Against Tuberculosis (PhilCAT).Treatment of pulmonary and extra-pulmonary tuberculosis in adults. In: Clinical practice guidelines for the diagnosis, treatment, prevention and control of tuberculosis in adult Filipinos: 2016 update. Philippines;2016.
Kow CY, Chan P, Etherington G, Ton L, Liew S, Cheng AC, Rosenfeld JV. Pan-spinal infection: a case series and review of the literature. J Spine Surg. 2016;2(3):202 –9. https://pubmed.ncbi.nlm.nih.gov/27757433 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067279 https://doi.org/10.21037/jss.2016.08.04
Roberts TT, Leonard GR, Cepela DJ. Classifications In Brief: American Spinal Injury Association (ASIA) Impairment Scale. Clin Orthop Relat Res. 2017;475(5):1499 – 1504. https://pubmed.ncbi.nlm.nih.gov/27815685 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384910 https://doi.org/10.1007/s11999-016-5133-4
Goel A. Tuberculosis of craniovertebral junction: Role of facets in pathogenesis and treatment. J Craniovertebr Junction Spine. 2016;7(3):129–30. https://pubmed.ncbi.nlm.nih.gov/27630471 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994141 https://doi.org/10.4103/0974-8237.188418
Wang XY, Luo CK, Li WW, Wu P, Pang XY, Xu ZQ, Zeng H, Peng W, Zhang PH. A practical therapeutic protocol for cervical tuberculosis. Eur J Trauma Emerg Surg. 2013;39(1):93-9. https://pubmed.ncbi.nlm.nih.gov/26814928 https://doi.org/10.1007/s00068-012-0243-5
Denis F. The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. Spine (Phila Pa 1976). 1983;8(8):817–31. https://pubmed.ncbi.nlm.nih.gov/6670016 https://doi.org/10.1097/00007632-198311000-00003
Qu JT, Jiang YQ, Xu GH, et al. Clinical characteristics and neurologic recovery of patients with cervical spinal tuberculosis: should conservative treatment be preferred? A retrospective follow-up study of 115 cases. World Neurosurg. 2015;83(5):700–7. https://pubmed.ncbi.nlm.nih.gov/25681590 https://doi.org/10.1016/j.wneu.2015.01.015
Zeng H, Shen X, Luo C, Xu Z, Zhang Y, Liu Z, Wang X. Comparison of three surgical approaches for cervicothoracic spinal tuberculosis: a retrospective case-control study. J Orthop Surg Res. 2015;10:100. https://pubmed.ncbi.nlm.nih.gov/26135121 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490609 https://doi.org/10.1186/s13018-015-0238-0
Xing X, Yuan H. Imaging and differential diagnosis of pediatric spinal tuberculosis. Radiology of Infect Dis. 2015:1(2):78–82. https://doi.org/10.1016/j.jrid.2015.02.005
Benzagmout M, Boujraf S, Chakour K, Chaoui Mel F. Pott's disease in children. Surg Neurol Int. 2011;2:1. https://pubmed.ncbi.nlm.nih.gov/21297923 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031051 https://doi.org/10.4103/2152-7806.75459
Kumar R, Srivastava AK, Tiwari RK. Surgical management of Pott's disease of the spine in pediatric patients: a single surgeon's experience of 8 years in a tertiary care center. J Pediatr Neurosci. 2011;6(Suppl 1):S101–8. https://pubmed.ncbi.nlm.nih.gov/22069419 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208916 https://doi.org/10.4103/1817-1745.85726
Kato S, Oshima Y, Oka H, et al. Comparison of the Japanese Orthopaedic Association (JOA) score and modified JOA (mJOA) score for the assessment of cervical myelopathy: a multicenter observational study. PLoS One. 2015 Apr 2;10(4):e0123022. https://pubmed.ncbi.nlm.nih.gov/25837285 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383381 https://doi.org/10.1371/journal.pone.0123022. Erratum in: PLoS One. 2015;10(5):e0128392. https://pubmed.ncbi.nlm.nih.gov/25962061
Harrop JS, Sharan AD, Przybylski GJ. Epidemiology of spinal cord injury after acute odontoid fractures. Neurosurg Focus. 2000;8(6):e4. https://pubmed.ncbi.nlm.nih.gov/16859273
Shetty AP, Viswanathan VK, Rajasekaran S. Cervical spine TB - current concepts in management. J Orthop Surg (Hong Kong). 2021;29(1_suppl):23094990211006936. https://pubmed.ncbi.nlm.nih.gov/34711081 https://doi.org/10.1177/23094990211006936
Eck J, Kim C, Currier K, Eismont F. Infections of the spine. In: Rothman- Simeon and Herkowitz, 7th ed. Philadelphia: PA Saunders; 2018.
Govender S, Ramnarain A, Danaviah S. Cervical spine tuberculosis in children. Clin Orthop Relat Res. 2007;460:78–85. https://pubmed.ncbi.nlm.nih.gov/17620809